Researchers at the University of Kent have identified a plant derived compound from Centella asiatica with potential to tackle antibiotic resistant infections. The ingredient, known as madecassic acid, is widely used in skincare but is now attracting attention for its antimicrobial properties.

Working with collaborators at University College London, scientists combined computational analysis with laboratory testing to explore how the compound affects harmful bacteria. The study found that it can inhibit the growth of drug resistant E. coli by targeting a bacterial respiratory system that is not present in humans.

This selective mechanism makes the compound a promising candidate for future antibiotic development. Researchers also created modified versions of the molecule, with early results showing improved activity and, in some cases, the ability to kill bacteria at higher concentrations.

With antimicrobial resistance predicted to cause millions of deaths in coming decades, the discovery highlights the growing importance of natural products in drug discovery. The team plans to continue refining the compound to support potential clinical use.