Rectal Cancer Therapeutics Pipeline Analysis and Developments

Rectal Cancer Therapeutics currently exhibits a proliferating pipeline with 10+ therapeutic candidates.

Rectal cancer, also known as colon cancer, bowel cancer, or colorectal cancer, is the growth of malignant and cancerous cells in the lower part of the colon. This cancer first develops as polyp, which further becomes malignant. In general, rectal cancer occurs due to changes in DNA of healthy cells present in the rectum. However, in most cases, the cause of these changes is unknown. Some of the risk factors that can cause rectal cancer include aging, smoking, inflammatory bowel disease (IBD), family or personal history of colon or rectal cancer, and high fat diet or diet mostly from animal sources, alcohol consumption, and sedentary lifestyle. Commonly occurring symptoms of the cancer include bloody stool, abdominal pain, iron deficiency, diarrhea, and weight loss.

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According to the research findings, majority of pipeline drug candidates are being developed for oral administration. It has been observed that the oral route of medications is convenient, available in delayed or rapid release formulation, less risk of systemic infections, and inexpensive in nature, and also provides improved patient’s compliance. Administration of therapeutics for rectal cancer through oral route has shown promising results in clinical studies.

Companies that are involved in developing therapeutics for rectal cancer have shown positive clinical results in the various phases of drug development. For instance, in 2017, Hutchison MediPharma announced positive topline result of trial of fruquintinib in 416 patients with locally advanced or metastatic colorectal cancer.

Eli Lilly and Company, Taiwan Liposome Company Ltd., Genentech Inc., Sanofi-aventis Groupe, Merck & Co. Inc., Bristol-Myers Squibb Company, Hutchison MediPharma, Seattle Genetics Inc., and Advaxis Inc. are some of the key players involved in the development of drugs for rectal cancer.