Plant-based Biologics Market Size, Share 2019 Industry Analysis Future Trends, Growth Factors, Historical Overview, Business Insights and Regional Forecast to 2026

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Global Plant-based Biologics Market

Rising demand for human biologics cannot be fulfilled by currently used mammalian cell culture production platforms, as these platforms are highly expensive and have limited scalability. However, recent developments in plant expression vectors, downstream processing, and glycoengineering have established plants as a superior alternative to biologic production. Plants not only offer the traditional benefits of proper eukaryotic protein modification, but also have the potential to develop biologics at a lower cost with high scalability. They increase the production of biologics at unprecedented speed and also helps in controlling potential pandemics for better efficacy or safety.

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Plant-based biologics is likely to turn out as the next major commercial development in the field of biotechnology. Some of the advantages offered in terms of product safety, production scale and economy, ease of storage, and distribution cannot be fulfilled at same time by any other current commercial system. They also provide the opportunity to supply low-cost drugs and vaccines to the emerging economies.

Usage of plant-based cell line instead of mammal cell lines to produce biologic drugs came to the forefront when various companies were trying to scale up the alternative process in an effort to produce treatment for Ebola. The approval of the first plant-made biologic (PMB) – taliglucerase alfa for injection by the U.S. Food and Drug Administration (USFDA) for treating Gaucher’s disease in 2012 proclaimed a new era for PMBs and triggered the innovation in the biopharmaceuticals sector.

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Global Plant-based Biologics Market Dynamics

Escalating demand for biologics for the treatment of various chronic diseases, coupled with rising investment in R&D for the production of biologics, is expected to contribute significantly to the growth of the global plant-based biologics market. According to the Biotechnology Innovation Organization (BIO) 2015, over 250 biologic therapies and vaccines have changed the lives of hundreds of millions of patients. Moreover, according to the same source, over 900 biologics are currently (2018) under the stage of development for over 100 diseases in the U.S. According to the Pharmaceutical Research and Manufacturers of America (PhRMA), 2016, member companies invested around US$ 58.8 billion in research and development in 2015, of which, majority of the investment was made by all the biopharmaceutical companies in the U.S. for the treatment of rare diseases.

Several biopharmaceutical companies are entering into developing plant-made pharmaceuticals using various plants such as tobacco, duckweed, moss, alfalfa, and other plants, which is expected to propel growth of the plant-based biologics market. For instance, in September 2015, LeafBio, Inc., the commercial partner of Mapp Biopharmaceutical, Inc. (Mapp), was granted fast track designation by the U.S. Food and Drug Administration (FDA) for their plant-made drug, called ZMapp, for the treatment of the Ebola virus disease.

However, stringent regulatory guidelines for the production of plant-based biologics is one of the major factors restraining growth of the plant-based biologics market. Moreover, concern regarding contamination and environmental risks is another factor restraining the growth of the global market.

Global Plant-based Biologics Market – Regional Analysis

North America is expected to stand out as the most lucrative region in the global plant-based biologics market over the forecast period. Market development in this region is attributed to the presence of various private and government research organizations, which are highly focused on R&D activities to develop plant-based biologics in this region. For instance, Fraunhofer Center for Molecular Biotechnology completed phase I clinical trials for the study of safety and immunogenicity of plant-derived recombinant protective antigen (Biological: PA83-FhCMB) for anthrax vaccine in healthy adults in year 2015. Furthermore, key players in North America are looking to carry out clinical trials to develop plant-based biologics for the treatment of various chronic diseases, which is further expected to drive growth of the plant-based biologics market in this region.

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Global Plant-based Biologics Market – Competitive Analysis

The major players operating in the global plant-based biologics market include PlantForm, IBio Inc., Mapp Biopharmaceutical, Inc., Pfizer Inc., Ventria Bioscience, Medicago Inc., Greenovation Biotech GmbH, Kentucky BioProcessing, PhycoBiologics Inc., Synthon, Fraunhofer IME, Healthgen, PlanetBiotechnology, and Icon Genetics GmbH.

These companies focused on adopting a multitude of business growth strategies, including collaborations, mergers & acquisitions, and new product launches, in order to sustain their dominant positions in the global market. For instance, in August 2017, Japanese company named Denka acquired German plant biotech Icon Genetics Inc. for approximately US$ 85.0 million. This acquisition will help Denka to focus on research and development in the vaccines and diagnostic reagents business and to continue development of new biopharmaceuticals, including biosimilar and ‘biobetter’ antibodies.

Market Taxonomy

On the basis of plant system:

• Leaf-based
• Seed-based
• Fruit-based
• Tuber-based
• Others

On the basis of source:

• Carrot
• Tobacco
• Duckweed
• Rice
• Moss
• Alfalfa
• Others

On the basis of geography:

• North America
• Latin America
• Europe
• Asia Pacific
• Middle East
• Africa

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