Single Cell Analysis Market Insights 2019 | Segmentation, SWOT Analysis And Applications Till 2026 | CMI

Single Cell Analysis Market – Insights

Single-cell analysis aids in sequencing of whole human genome at a single-cell level and measures and analyzes cellular heterogeneity. The approach finds application in genomics, transcriptomics, proteomics, epigenomics, metabolomics, and medicine. Next-generation sequencing and third-generation sequencing are widely used in genomics.

A study published in the Journal of Single Cell Analysis in 2014 stated that a variety of technologies that are powerful and less expensive such as Multiple Annealing and Looping-Based Amplification Cycle (MALBAC) and Multiple Displacement Amplification (MDA) can be used in uncovering somatic mutations in human genome and detection of copy number variation. However, in human single-cell genomics, Whole Genome Sequencing or Whole Exome-Sequencing (WGS or WESseq) finds great potential in clinical applications, especially in screening, diagnosis, and monitoring. Single-cell analysis is also used in academic research.

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Several samples such as stem cells, immune cells, neurons, cancers, and other tissues demonstrate a stochastic nature with heterogeneity factor. Use of conventional methods fails to offer transcriptomic profile in highly heterogeneous cell population. This in turn increases preference for single-cell technology. Single cell analysis allows to recognize biomarkers of delicate phenotypes or disorders (e.g. cancer stem cells) even when the cell population is low. Moreover, single cell analysis also aids to sort various cell types in different physiological and pathological conditions, in very rare events of any somatic mutation, epigenetic modification of regulatory gene expression, and its function.

Global Single Cell Analysis Market: Drivers

Increasing development of new products is expected to boost growth of the global single cell analysis market. For instance, in 2017, 10x Genomics, launched the chromium single cell V(D)J solution for profiling full length paired V(D)J transcripts from hundreds to millions of lymphocyte. It is a reagent system, which has the ability to completely identify and characterize T and B cells by single cell sequencing. This will reveal true clonality and diversity in adaptive immune system.

Moreover, increasing adoption of stem cell therapy and in-vitro fertilization (IVF) and long shelf life of single cell analysis products and consumable products is expected to contribute to growth of the market.

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Global Single Cell Analysis Market: Restraints

However, high cost of instruments required in single cell analysis is expected to hinder growth of the market.

Global Single Cell Analysis Market: Trends and Opportunity

A study by the Journal of Analytical and Bioanalytical Chemistry in 2014 stated that Inductively Coupled Plasma Mass Spectroscopy (ICP-MS) and ICP Optical Emission Spectrometry (ICP-OES) are applied using metal atoms such as nanoparticle for investigation of cell-to-cell variance or cellular uptake of drugs and other elements.

Single-cell genomics find many clinical applications such as genetic diagnosis of embryo-related diseases and to study blood-borne Circulating Tumor Cells (CTCs). These applications may be further employed for diagnosis, prognosis, and treatment of cancer.

Global Single Cell Analysis Market: Trends and Opportunity

Global Single Cell Analysis Market: Competitive Landscape

Major players operating in the global single-cell analysis market include, Bio-Rad Laboratories, Inc., Bio-Techne Corporation, 10X Genomics, Abcam Plc., Agilent Technologies, Fluxion Biosciences, Becton, Dickinson and Company, Bruker, Danaher Corporation, Fluidigm Corporation, GE Healthcare, and Illumina.

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Key Developments in Single Cell Analysis Market

• In June 2019, Proteona Pte. Ltd. launched its latest ESCAPE proteogenomics assay, for the characterization of Chimeric Antigen Receptor (CAR) T cell. The Proteona CAR-T assay is based on the Enhanced Single Cell Analysis with Protein Expression (ESCAPE) RNA sequencing technology.
• In March 2019, Mission Bio launched Tapestri Designer, an automated cloud-based tool for designing targeted single-cell DNA custom panels. It is an easy-to-use web interface and will create custom panels in minutes for the Tapestri Platform.
• In November 2018, Dolomite Bio launched high throughput single nuclei RNA sequencing (sNuc-Seq) protocol for its Nadia Instrument. It enables researchers to profile both complex and archived tissues for accelerating disease and drug discovery research in therapeutic areas such as oncology and neurology.
• In September 2018, Bio-Rad Laboratories, Inc. launched its scATAC-Seq solution, a single-cell assay for transposase-accessible chromatin using sequencing. The solution enables genome-wide open chromatin sequencing at the single-cell level with the help of company’s proprietary ddSEQ Single-Cell Isolator.
• In June 2018, New England Biolabs (NEB) launched NEBNext Single Cell/Low Input RNA Library Prep Kit for Illumina. The new kit can produce full-length transcript sequence-ready libraries from single cells and ultra-low input RNA when incorporated with optimized template switching protocol and NEB’s Ultra II FS enzymatic DNA fragmentation technology.
• In September 2017, Becton, Dickinson and Company launched BD Rhapsody, a single-cell analysis platform. The platform has been designed to perform gene expression profiling. It can detect rare molecules responsible for biological diversity that are often missed with whole-transcriptome profiling.

Global Single Cell Analysis Market Taxonomy

The global single-cell analysis market is segmented on the basis of product, types of cells, type of technique, application, and end-user.

By product:

• Consumables (beads, microplate, reagents, assay kits, etc.)
• Instruments (PCR, NGS system, spectrophotometers, etc.)
  • Automated
  • Manual

By Types of cells:

• Human
• Animal
• Microbial

By Type of technique:

• Mass Spectroscopy (MS)
• Polymerase Chain Reaction (PCR)
• Next-Generation Sequencing
• Flow Cytometry
• Microscopy

By Application:

• Research
• Diagnostic applications
  • Noninvasive Prenatal Diagnosis (NIPD)
  • In Vitro Fertilization (IVF)
  • Circulating Tumor Cells (CTCs)

By End User:

• Academic & Research Institutes
• Biotechnology and Biopharmaceutical Companies
• Hospitals and Diagnostic Laboratories
• Cell Banks and IVF Centers

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