Creative Diagnostics Launches Upconversion Nanoparticles with Different Surface Ligands

With years of experience in the pharmaceutical and life science sector, Creative Diagnostics recently introduces a comprehensive list of upconversion nanoparticles with different surface ligands and variable emission range. These new products contain NaYREF4 (RE:Yb, Er, Tm, Gd, Mn, Lu) with Yb3+ as sensitizer and Er3+ or Tm3+ as activator and can be applied in various fields including molecular recognition, bioimaging, biosensors, light-responsive drug release, immunoassay, and flow cytometry.

Creative Diagnostics provides highly uniform nanoparticles widely used in biology and medicine, such as silver nanoparticles and quantum dots, which are manufactured with different shapes and sizes, and the particle surface can be coated, functionalized or conjugated with biomolecules. Upconverting nanoparticles can convert near infrared radiations with lower energy into visible radiations with higher energy via a nonlinear optical process. The doping concentrations and the size of upconverting nanoparticles can be customized based on researchers' specific requirements. These new upconversion nanoparticles have lots of advantages, like being monodisperse without agglomeration and aggregation, high quantum efficiency and good stability, water or ethanol soluble, and variable surface modification for different biomedical application.

For instance, Oil dispersible upconverting nanoparticles, Core-shell (DNL-B013), are absorbance max 975 nm, emission wavelength 545 nm and 660 nm, brown, viscous gel, with purity: >95.0%. With a hemogeneous material coated, luminous intensity of core-shell upconverting nanoparticles is improved greatly. These nanoparticles can be used for molecular recognition, biosensing, fluorescence imaging, biodetection, photodynamic therapy, and anti-cancer drug photoactivation. Creative Diagnostics also offers Custom Upconverting Nanoparticle Conjugation services for clients.

"Our upconverting nanoparticles can either be oil or water dispersible. By precise surface modification, these upconverting nanoparticles are available with coated, amine functionalized and antibody conjugated forms. These photoluminescent nanoparticles can be used for bio-imaging, molecular recognition and photodynamic therapy, and we believe researchers can find what they need at Creative Diagnostics," said Dr. Jessica Waldorf, chief scientific officer of R&D department, at Creative Diagnostics.

"Creative Diagnostics always makes efforts to provide full support to scientists and academic and industrial professionals, and the addition of these innovative upconversion nanoparticles products to our existing portfolio will further enable our clients to gain reliable and accurate research data and accelerate the progress of their bio-study," said Alex, one of a senior scientific officers at Creative Diagnostics.

For more detailed information on upconversion nanoparticles or to discuss your project, please contact Creative Diagnostics directly. You'll find more about their newly released products and services.

About Creative Diagnostics

Creative Diagnostics is a global leading manufacturer and supplier of various nanoparticles, microparticles and their coatings for R&D and commercialization in a wide variety of application areas including in vitro diagnostics, biochemistry, cellular analysis, cell separation, and immunoassay. It also offers various custom services including chemical surface-functionalized, fluorescent modification, antibody immobilization, nucleic acid and oligo conjugation to meet clients' specifications.