Avascular Necrosis Market is estimated to be valued at US$ 840 Million with CAGR of 6.0% by 2026 – Coherent Market Insights
SEATTLE, April 12, 2021, (PHARMIWEB) — Avascular necrosis (AVN) is also referred to as osteonecrosis, or aseptic necrosis, or ischemic bone necrosis. It is a medical condition where cells of bone marrow die due to lack of blood supply. Avascular necrosis affects the ends (epiphysis) of long bones such as femur, upper humerus, and bones of ankle joint. This is caused by various factors such as smoking, metabolic, genetic, increased alcohol consumption, and other diseases. On the basis of cause, avascular necrosis can be classified as traumatic and non-traumatic avascular necrosis.
An X-ray is usually used to analyze the cause of joint pain. However, magnetic resonance imaging (MRI), is also used to diagnose avascular necrosis in the early stages. Unlike X-rays, bone scans, and computed/computerized tomography (CT) scans, MRI determines the chemical changes in the bone marrow and shows avascular necrosis in its earliest stages.
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Nonsurgical treatment is usually opted for treating avascular necrosis. This includes anti-inflammatory medications, activity changes, and crutches that can help relieve pain. Surgical treatment includes core decompression, bone and cartilage grafting, and total hip replacement.
According to the Science Direct Journal 2010 report, traumatic injury such as ankle sprain, fracture, and joint dislocation is the most common cause of AVN, which can occur eight hours after disruption to the blood supply. Non-traumatic avascular necrosis occurs usually at a young age and it is caused due to chronic liver disease, corticosteroids, decompression sickness, fat embolism syndrome, Gaucher disease, gout, hyperlipidaemia, haemoglobinopathy, metabolic bone disease, systemic chemotherapy systemic lupus erythematosus, and alcoholism among others.
The global avascular necrosis market size was valued at US$ 512.9 million in 2017 and is projected to witness a CAGR of 6.0% over the forecast period (2018 – 2026).
Global Avascular Necrosis Market Value (US$ Mn) & Y-o-Y Growth (%)
Source: Coherent Market Insights Analysis (2018)
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Growing alcohol Consumption and Use of Corticosteroids are projected to fuel the growth of the Avascular Necrosis Market
Excessive alcohol consumption and a high dose of systemic corticosteroid are the major risk factors for developing avascular necrosis. According to the World Journal of Orthopedics, 2015, avascular necrosis usually affects people between 30 and 50 years of age. Also, from the same source, about 10,000 to 20,000 people develop osteonecrosis each year in the U.S. According to National Organization for Rare Disorders’ 2015 data, alcohol consumption and corticosteroid use affect about 30% and 35% of all people with non-traumatic avascular necrosis, respectively across the globe.
Other risk factors or conditions associated with non-traumatic osteonecrosis are an autoimmune disease, cancer, decompression disease (Caisson disease), Gaucher disease, pancreatitis, HIV infection, and blood disorders such as sickle cell disease. Some of the medical treatments are radiation therapy and chemotherapy. Also, people who have undergone organ transplants are prone to develop the risk of osteonecrosis.
Innovation in therapies for avascular necrosis such as Advanced Therapy Medicinal Products (ATMPs) is projected to boost avascular necrosis market growth.
Market Restraints
However, the high cost of surgical treatments and delays in diagnosis due to the asymptomatic nature of this condition at an early stage are the major factors hindering the market growth of avascular necrosis market growth. For instance, according to Blue Cross Blue Shield of North Carolina, a total hip replacement procedure usually cost between US$ 31,839 and US$ 44,816, with an average cost of US$ 39,299.
Regional Insights
On the basis of region, the global avascular necrosis market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America is projected to generate a significant revenue share in the global avascular necrosis market over the forecast period and this can be attributed to rising prevalence of avascular necrosis and prior Food and Drug Administration (FDA) approval for the new avascular necrosis treatments in the region. For instance, according to the National Center for Biotechnology Information (NCBI), 2015, about 20,000 to 30,000 new patients are diagnosed with avascular necrosis every year in the U.S.
Asia Pacific avascular necrosis market is projected to foresee the highest growth rate over the forecast period, and this can be attributed to increasing research activities for the development of treatment of avascular necrosis by various key players in this region. For instance, in 2017, Asahi Kasei Corporation and Bone Therapeutics signed a license agreement for the development and commercialization of PREOB in Japan. PREOB is an autologous osteoblastic cell therapy product derived from ex vivo cultured bone marrow cells of the patients.
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Global Avascular Necrosis Market Share 2017 (%), By Region
Source: Coherent Market Insights Analysis (2018)
Competitive Landscape
Key players operating in the global avascular necrosis market include Bone Therapeutics, Boehringer Ingelheim GmbH, Bayer AG, Enzo Biochem Inc., Ethicon Inc., Eli Lilly and Company, Grifols SA, Integra LifeSciences Corporation, K-Stemcell Co Ltd., Medtronic Plc, Merck KGaA, Pfizer Inc., Sanofi SA, Stryker Corporation, Wright Medical Group N.V., and Zimmer Biomet Holdings. Manufacturers are focusing on advancements in treatment technologies such as gene therapy and stem cell-based treatment for avascular necrosis.
Table of Contents
- Research Objective and Assumption
- Research Objectives
- Assumptions
- Abbreviations
- Market Overview
- Report Description
- Market Definition and Scope
- Executive Summary
- Market Snippet, By Type
- Market Snippet, By Treatment
- Market Snippet, By Region
- Coherent Opportunity Map (COM)
- Report Description
- Market Dynamics, Regulations, and Trends Analysis
- Market Dynamics
- Drivers
- Restraints
- Market Opportunities
- Impact Analysis
- Market Trends
- Key Developments
- Technological Advancements
- Epidemiology Analysis
- PEST Analysis
- Pipeline Analysis
- Market Dynamics
- Global Avascular Necrosis Market, By Type, 2016 – 2026, (US$ Million)
- Introduction
- Market Share Analysis, 2018 and 2026 (%)
- Y-o-Y Growth Analysis, 2016 – 2026
- Segment Trends
- Trauma Related Avascular Necrosis
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
- Non-Trauma Related Avascular Necrosis
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
- Introduction
- Global Avascular Necrosis Market, By Treatment, 2016 – 2026, (US$ Million)
- Introduction
- Market Share Analysis, 2018 and 2026 (%)
- Y-o-Y Growth Analysis, 2016 – 2026
- Segment Trends
- Drug-Based
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
- Surgery-Based
- Introduction
- Market Size and Forecast, and Y-o-Y Growth, 2016 – 2026, (US$ Million)
- Core decompression surgery
- Osteotomy
- Bone graft
- Total joint replacement
- Introduction
- Global Avascular Necrosis Market, By Region, 2016 – 2026, (US$ Million)
- Introduction
- Market Share Analysis, By Region, 2018 and 2026 (%)
- Y-o-Y Growth Analysis, By Region, 2016 – 2026
- Regional Trends
- North America
- Market Size and Forecast, By Type, 2016 – 2026, (US$ Million)
- Market Size and Forecast, By Treatment, 2016 – 2026, (US$ Million)
- Market Size and Forecast, By Country, 2016 – 2026, (US$ Million)
- U.S.
- Canada
- Europe
- Market Size and Forecast, By Type, 2016 – 2026, (US$ Million)
- Market Size and Forecast, By Treatment, 2016 – 2026, (US$ Million)
- Market Size and Forecast, By Country, 2016 – 2026, (US$ Million)
- U.K.
- Germany
- Italy
- France
- Spain
- Russia
- Rest of Europe
- Asia Pacific
- Market Size and Forecast, By Type, 2016 – 2026, (US$ Million)
- Market Size and Forecast, By Treatment, 2016 – 2026, (US$ Million)
- Market Size and Forecast, By Country, 2016 – 2026, (US$ Million)
- China
- Japan
- India
- ASEAN
- Australia
- South Korea
- Rest of Asia Pacific
- Latin America
- Market Size and Forecast, By Type, 2016 – 2026, (US$ Million)
- Market Size and Forecast, By Treatment, 2016 – 2026, (US$ Million)
- Market Size and Forecast, By Country, 2016 – 2026, (US$ Million)
- Brazil
- Mexico
- Argentina
- Rest of Latin America
- Africa
- Market Size and Forecast, By Type, 2016 – 2026, (US$ Million)
- Market Size and Forecast, By Treatment, 2016 – 2026, (US$ Million)
- Market Size and Forecast, By Country, 2016 – 2026, (US$ Million)
- Northern Africa
- Central Africa
- South Africa
- Middle East
- Market Size and Forecast, By Type, 2016 – 2026, (US$ Million)
- Market Size and Forecast, By Treatment, 2016 – 2026, (US$ Million)
- Market Size and Forecast, By Country, 2016 – 2026, (US$ Million)
- GCC Countries
- Israel
- Rest of Middle East
- Introduction
- Competitive Landscape
- Heat Map Analysis
- Company Profiles
- Company Overview
- Product Portfolio
- Financial Performance
- Recent Highlights
- Strategies
- Analyst Views
- Section
- References
- Research Methodology
- About us and Sales Contact
Coherent Market Insights is a global market intelligence and consulting organization focused on assisting our plethora of clients achieve transformational growth by helping them make critical business decisions. We are headquartered in India, having office at global financial capital in the U.S. and sales consultants in United Kingdom and Japan. Our client base includes players from across various business verticals in over 150 countries worldwide. We pride ourselves in catering to clients across the length and width of the horizon, from Fortune 500 enlisted companies, to not-for-profit organization, and startups looking to establish a foothold in the market. We excel in offering unmatched actionable market intelligence across various industry verticals, including chemicals and materials, healthcare, and food & beverages, consumer goods, packaging, semiconductors, software and services, Telecom, and Automotive. We offer syndicated market intelligence reports, customized research solutions, and consulting services.
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