[2021] BRAF Kinase Inhibitors Market – Global Exclusive Analysis by Leading Players Overview by 2027 | F. Hoffmann-La Roche AG, Novartis International AG, and Pfizer, Inc.

SEATTLE, April 14, 2021, (PHARMIWEB) — Overview:

BRAF is a kinase compound that helps control cell development and signalling. It very well might be found in a transformed (changed) structure in certain kinds of disease, including melanoma and colorectal cancer. Impeding blocked BRAF kinase proteins assists with preventing the cancer cells from developing. Some BRAF kinase inhibitors are utilized to treat cancer.

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Covid-19 Impact:

As Covid-19 has spread across the globe, it has made significant disturbance across networks, clinics, and other medical services settings. Clinical trials are additionally being seriously affected with disturbances in both new enlistment and in continuing to keep patients on treatments. As indicated by the clinicaltrial.gov, as of April 2020, there were in excess of 2,850 trails and around 900,000 patients selected at trail destinations in areas that were in partial or complete lockdown because of COVID-19 limitations.

Drivers:

Approval and launch of new products is expected to propel growth of the Braf kinase inhibitors market. For instance, in July 2020, Roche reported that the U.S. Food and Drug Administration approved Tecentriq (atezolizumab) in addition to Cotellic (cobimetinib) and Zelboraf (vemurafenib) for the treatment of BRAF V600 mutation positive progressed melanoma patients.

Moreover, R&D in BRAF family kinase inhibitors is also expected to aid in growth of the market. For example, For instance, in June 2020, BeiGene, Ltd., a business stage biotechnology organization and SpringWorks Therapeutics, Inc., a clinical-stage biopharmaceutical organization, declared the introduction of preclinical information and gave a program update on their progressing Phase 1b/2 examination assessing the blend of BeiGene’s investigational RAF dimer inhibitor, lifirafenib, with SpringWorks’ investigational MEK inhibitor, mirdametinib, in patients with cutting edge or hard-headed strong tumors holding transformations in the MAPK pathway, incorporating those with RAS changes.

Moreover, increasing prevalence of metastatic cancer is also expected to boost the BRAF kinase inhibitors market. For instance, as per the Centers for Disease Control and Prevention gave information to 2012 to 2016, around 77,698 new instances of melanoma cancer (45,854 among men and 31,845 among ladies) were analyzed each year in the U.S. Also, the American Cancer Society assessed that around 100,350 new instances of melanoma will be analyzed and around 6,850 casualties are assessed to happen because of melanoma in the U.S. in 2020.

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Restraints:

High cost of cancer treatment is expected to hinder the growth of BRAF kinase inhibitors market. For instance, as indicated by information published in National Center for Biotechnology Information (NCBI), by Experimental Hematology and Oncology, by year 7 of metastatic cancer, the aggregate expenses each month were US$ 4,281 for ipilimumab, contrasted with US$ 8,920 for dabrafenib, US$ 10,211 for trametinib, US$ 11,002 for vemurafenib, and US$ 19,132 for dabrafenib + trametinib mix treatment.

The BRAF kinase inhibitors market is estimated to be valued at US$ 924.8 million in 2020 and is expected to exhibit a CAGR of 8.6% during the forecast period (2020-2027).

Market Taxonomy:

BRAF kinase inhibitors market by drug is segmented into:

• Vemurafenib
• Dabrafenib
• Lifirafenib
• Encorafenib

By Indication:

• Metastatic Melanoma
• Metastatic Lung Cancer
• Others

By Distribution Channel:

• Hospital Pharmacies
• Retail Pharmacies
• Online Pharmacies

By Region:

• North America
• Latin America
• Europe
• Asia Pacific
• Middle East
• Africa

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Regional Analysis:

North America is expected to witness significant growth in BRAF kinase inhibitors market owing to increasing number of product approvals by the regulatory authorities. For instance, in July 2020, the U.S. Food and Drug Administration (FDA) endorsed the PD-L1 inhibitor atezolizumab (Tecentriq) in addition to the MEK inhibitor cobimetinib (Cotellic) and the specific BRAF kinase inhibitor vemurafenib (Zelboraf) for the treatment of patients with cutting edge BRAF V600 transformation positive melanoma. The endorsement depends on outcomes from IMspire150, a multicenter, twofold visually impaired, fake treatment controlled randomized stage III investigation.

In addition, Europe is also expected to witness significant growth in BRAF kinase inhibitors market over the forecast period. In September 2018, Pierre Fabre declared that the European Commission (EC) allowed promoting approval for the blend of BRAFTOVI (encorafenib) and MEKTOVI (binimetinib) for the treatment of grown-up patients with unresectable or metastatic melanoma with a BRAFV600 change, as distinguished by an approved test. The EC choice is relevant to every one of the 28 European Union (EU) part states and Liechtenstein, Iceland, and Norway.

Competitive Section:

Major players involved in BRAF kinase inhibitors market are F. Hoffmann-La Roche AG, Novartis International AG, and Pfizer, Inc.

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