CD Formulation Releases Solubility Analysis to Assist Drug R&D Projects

Solubility measurement is a key element for a preliminary understanding of the pharmacodynamic properties of the drug. On August 30, 2021, CD Formulation, a leading CRO service provider in the industry, announces the release of drug solubility analysis, which is an indispensable step in drug development and formulation to ensure efficacy and quality of drugs.

Drug substances have to be dissolved before they can be absorbed. Therefore, the appropriate analysis and optimization of solubility is of paramount significance for drug formulation to enhance its pharmacokinetic and therapeutic effects.

“By definition, solubility means the maximum amount of a substance that will dissolve in a given amount of solvent at a specified temperature,” says the Marketing Chief of CD Formulation. ”We have a set of criteria for solubility analysis. Before analysis, we must make sure that the sample collection method is reasonable, a saturated solution is obtained, the analytical method is reliable, and the temperature is properly controlled.”

A lot of factors can affect the solubility of candidate drug molecules, for example, molecular structure of solute, nature of solvent or co-solvents, crystal characteristics, particle size of the solid, complex formation, pH, common ion effect, effect of indifferent electrolytes on the solubility product, effect of electrolytes on the solubility of non-electrolytes, etc.

Based on the drug characteristics and delivery requirements, appropriate methods can be chosen for efficient solubility and pharmacokinetics enhancement of lipophilic drugs. “Our methods of solubility improvement include: chemical modification of drug molecule, use of co-solvent, particle size reduction, hydrotropy, addition of surfactant or solubilizing agent, ionization and pH optimization or adjustment, temperature change, complexation and more,” further explains the Marketing Chief.

The solubility analysis services offered by CD Formulation aim to build a full range pH solubility profile and investigate the solubility in simulated gastrointestinal media so as to find ways to improve solubility.

Besides providing dissolution profiles of active pharmaceutical ingredients in various solvents such as inorganic solvents with different pH values, organic solvents, simulated intestinal juice or gastric juice, and other solvents, CD Formulation is also capable of performing dissolution testing under specified conditions according to specific applicable pharmacopoeial standards. Visit: https://www.formulationbio.com/ to learn more relevant details.

About CD Formulation

Evers since its establishment, CD Formulation has been working hard to innovate drug formulation, trying to meet the increasing market demand for a more flexible and efficient drug development system. Although challenges and difficulties still exist, the company has successfully found a more intelligent approach to excipient design in the hope to address the long-standing issue of poor solubility and bioavailability of newer APIs. Equipped with a group of experienced staff, CD Formulation is working closely with the pharmaceutical industry as a contract service organization, offering outstanding expertise to handle complex drug formulation issues.