LIfT BioSciences and Minaris Regenerative Medicine Enter into a Development and Manufacturing Partnership for N-LIfT Allogeneic Neutrophil Based Cell Therapy

LONDON, UK and MUNICH, Germany, February 16, 2023 / B3C newswire / -- LIfT BioSciences, a pioneering pre-clinical stage company moving into first-in-human trials with an allogeneic neutrophil progenitor based cell therapy, and Minaris Regenerative Medicine GmbH, a leading global contract development and manufacturing service provider for the cell and gene therapy industry, have entered into a development and manufacturing partnership for N-LIfT, LIfT’s first-in-class neutrophil progenitor based Leukocyte Infusion Therapy for the treatment of various cancer indications, including Pancreatic Cancer, Lung Cancer and other solid tumours. 

Under the terms of the agreement, Minaris, in conjunction with LIfT BioSciences are confident they can develop a Good Manufacturing Practice (GMP)-compliant manufacturing process to supply LIfT’s clinical trial programmes in Europe, currently anticipated to start in Q1 2024. N-LIfT is made from Immunomodulatory Alpha Neutrophils committed myeloid progenitors (IMANp) that are manufactured ex vivo from hematopoietic stem cells (HSCs) of healthy donors who exhibit exceptional innate cancer killing properties. The unique mechanism of action of N-LIfT allows the product to work effectively through the innate immune pathway as well as activating multiple other factors of the adaptive immune system.

“Following very strong preclinical results, we are now moving into producing GMP grade product as we prepare for clinical trials early next year. Our mission to destroy all solid tumours irrespective of where the tumour is or how it adapts is looking more and more achievable”, said Alex Blyth, CEO of LIfT BioSciences. “We are confident that Minaris’ extensive track record in process development, clinical, and commercial manufacturing will generate a scalable and cost-effective GMP-process and accelerate our clinical readiness.”

Dusan Kosijer, CEO of Minaris Regenerative Medicine GmbH commented: “We are excited about our partnership with LIfT BioSciences and to be contributing to scientific progress in a new field. We share LIfT’s enthusiasm about their unique IMANs and their demonstrated enhanced cytotoxic and immunomodulatory properties.”

About Minaris Regenerative Medicine
Minaris Regenerative Medicine is a global contract development and manufacturing organization (CDMO) for cell and gene therapies. We offer our clients high value clinical and commercial manufacturing services, development solutions, and technologies. We are pioneers in the field with more than 20 years’ experience providing outstanding quality and reliability. Our facilities in North America, Europe, and Asia allow us to supply life-changing therapies to patients globally. Minaris Regenerative Medicine is part of the Resonac Group.

About LIfT Biosciences
LIfT BioSciences is a pre-clinical stage company working towards first-in-human trials for our first generation ATMP, N-LIfT platform N-LIfT stands for Neutrophil based Leukocyte Infusion Therapy. The product is made from Immunomodulatory Alpha Neutrophil (IMANs) committed myeloid progenitors that are manufactured ex vivo from the HSPCs of healthy donors who exhibit exceptional innate cancer killing capabilities.

Contacts

Minaris Regenerative Medicine GmbH
Dr. Luc St-Onge
Global Head of Sales and Marketing
press@rm.minaris.de
+49 (0)89 700 9608-0

LIfT Biosciences
Alex Blyth, CEO
+44 (0)7718 759116            
ablyth@LIfTBioSciences.com

Consilium Strategic Communications
Lindsey Neville, Namrata Taak
liftbiosciences@consilium-comms.com

Forward-Looking Statements
This press release contains forward-looking statements which involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of the Company, or industry results, to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. LIfT BioSciences does not expect to update forward-looking statements continually as conditions change.

Keywords: Neutrophils; Hematopoietic Stem Cells; Neoplasms; Hematopoietic Stem Cell Transplantation; Regenerative Medicine; Cell- and Tissue-Based Therapy; Stem Cells; Bioreactors; Genetic Therapy; Pharmaceutical Preparations; Technology; Biotechnology; Commerce; Industry; Germany, United Kingdom

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