Transgene - Preclinical Results Showing TG6050, a Novel Oncolytic Virus, induces Tumor Regression by Activating Innate and Adaptive immune responses presented at AACR

Invir.IO® based oncolytic virus TG6050, is armed with IL-12 and an anti-CTLA4 antibody.  A Phase I trial (Delivir) recently started enrolling patients with advanced non-small cell lung cancer (NSCLC)

Strasbourg, France, April 17, 2023, 7:30 a.m. CET – Transgene (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapies for the treatment of cancer, presented promising preclinical data on its novel oncolytic virus TG6050, at the American Association for Cancer Research (AACR) Annual Meeting, April 14-19, 2023.

These data demonstrate the ability of TG6050 to induce strong antitumor responses through the production of IL-12 and anti-CTLA4 antibody in the tumor and the induction of innate and adaptive immune responses.

TG6050 is a clinical-stage oncolytic virus that has been engineered to encode human IL-12 and a full length anti-CTLA4 antibody. It is derived from the Invir.IO® platform and its patented
VV_COPTK^-RR^- viral vector which was shown to be well tolerated in humans and to replicate and express payloads in tumor tissues.

Key results of the poster are as follows:

• Sustained expression of IL-12 has been detected in tumors after intravenous and intratumoral administration of the murine version of TG6050 (mTG6050). The levels of functional IL-12 found in the tumor reach active concentrations. They are associated with low systemic exposure.
• mTG6050 treatment increased T cell responses capable of killing cancer cells.
• Transcriptomic and immunological analyses clearly show a remodeling of the tumor micro-environment and the activation of numerous innate and adaptive immune pathways.
• In several mice models, mTG6050 displayed a very strong anti-tumor activity.

Hedi Ben Brahim, Transgene’s CEO said, “We have designed TG6050, a novel oncolytic virus encoding the IL-12 and an anti-CTLA4, to generate both innate and adaptive immune responses. These outstanding pre-clinical findings clearly support the clinical development of TG6050, which has recently started the Phase I Delivir trial in patients with non-small cell lung cancer. We are confident that by generating similar effects in humans, TG6050 could become a new standard of care in patients with solid tumors.”

The Phase I Delivir trial has been initiated in 2023 and is currently enrolling patients with metastatic and recurring NSCLC.

Transgene will present a total of eight posters at AACR 2023 which all demonstrate the potential of the Company’s viral vectors in the treatment of solid tumors.