ProBioGen Launches Their Lentivirus Packaging Cell Line Lenti.RiGHT™ - A Shortcut to Successful Lentivirus Manufacturing

ProBioGen Launches Their Lentivirus Packaging Cell Line Lenti.RiGHT™ - A Shortcut to Successful Lentivirus Manufacturing

BOSTON, MA, USA and BERLIN, Germany, May 17, 2023 / B3C newswire / -- ProBioGen today announced the launch of their lentivirus (LV) packaging cell line Lenti.RiGHT™ as a new platinum standard for LV production at this year's PEGS Boston 2023. The lentivirus production platform is based on HEK293 packaging cells stably transfected with all necessary viral components. Dr. Volker Sandig, Chief Scientific Officer at ProBioGen discussed the advantages and results of the platform in his presentation.

Lentiviral vectors dominate the manufacturing of the CAR-T cells. The production of the lentiviruses is typically based on transient transfection where 4 GMP-grade bacterial plasmids have to be manufactured and co-introduced at bioreactor scale. The whole process is complex, not very robust and difficult to scale.

"With our Lenti.RiGHT platform we have developed a new standard for efficient large-scale lentivirus production and CAR-T manufacturing. It enables an inducible, scalable and efficient production of high-titer lentiviral particles for gene transfer applications", explained Dr. Volker Sandig.