Downstream Processing Market Sets New Record, Projected at USD 92 Billion by 2030 at 13.5 % CAGR | North America held the lion’s share
Key Takeaways:
- chromatography columns and resins segment would also exhibit the fastest CAGR of 14.7% from 2021 to 2030.
- The Asia-Pacific region, on the other hand, is expected to cite the fastest CAGR of 14.6% by the end of 2030.
- The purification segment exhibit the fastest CAGR of 14.4% throughout the forecast period.
Major Factors Driving the Growth of Downstream Processing Market:
- Biopharmaceutical Industry Expansion: The increasing demand for biopharmaceuticals, including monoclonal antibodies, vaccines, and gene therapies, has led to the growth of the downstream processing market. Biopharmaceuticals often require complex purification processes, spurring demand for downstream processing technologies.
- Rising Incidence of Chronic Diseases: The prevalence of chronic diseases like cancer, autoimmune disorders, and diabetes has boosted the development of biologics, driving the demand for downstream processing. These biologics often require sophisticated purification methods to ensure product safety and efficacy.
- Continuous Advances in Biotechnology: Ongoing advancements in biotechnology, such as cell culture techniques, genetic engineering, and protein expression systems, have increased the complexity of biopharmaceutical products. This complexity necessitates advanced downstream processing techniques to meet quality standards.
- Biosimilars Market Growth: The increasing development and approval of biosimilars, which are highly similar to existing biopharmaceuticals, have created a demand for efficient downstream processing methods to replicate the purity and safety of reference products.
- Global Pandemic Response: The COVID-19 pandemic highlighted the need for rapid vaccine development and manufacturing. This urgency drove investment in downstream processing technologies to accelerate vaccine production and distribution.
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Covid-19 scenario-
- Rise in demand for Covid-19 vaccines across the world impacted the global downstream processing market positively, since downstream process is an important method utilized for the production of vaccines.
- The key players in the industry also heightened their production to cater to the demand for products.
Market Segmentation:
Product Type:
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- Chromatography Systems: These systems are used for the separation and purification of biopharmaceutical products.
- Filters: Filters are used for clarification and sterilization during downstream processing.
- Centrifuges: Centrifugation is a common method for separating cells and cellular components in bioprocessing.
- Ultrafiltration/Diafiltration Systems: These systems are used for concentration, buffer exchange, and separation.
- Sorption Systems: Sorption processes include ion exchange, affinity chromatography, and hydrophobic interaction chromatography.
- Other Downstream Equipment: This category includes various other equipment like evaporators, crystallizers, and mixers.
Technique:
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- Affinity Chromatography: A technique that uses specific ligands to capture and purify target molecules.
- Ion Exchange Chromatography: A technique based on charge differences for separating molecules.
- Size Exclusion Chromatography: A technique that separates molecules based on their size.
- Hydrophobic Interaction Chromatography (HIC): A technique that separates molecules based on their hydrophobicity.
- Other Techniques: Other methods like precipitation, filtration, and crystallization.
Application:
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- Monoclonal Antibodies (mAbs) Production: Downstream processing is crucial for the production and purification of monoclonal antibodies.
- Vaccine Production: Purification and isolation processes are vital for vaccine manufacturing.
- Recombinant Proteins: Downstream processing is used in the production of various recombinant proteins.
- Gene Therapy Products: Isolation and purification of gene therapy vectors.
- Cell-Based Therapies: For the purification of cellular products and gene-edited cells.
- Other Biopharmaceuticals: Downstream processing is used in the production of various other biopharmaceuticals.
End User:
-
- Biopharmaceutical Companies: These companies are the primary users of downstream processing equipment.
- Contract Manufacturing Organizations (CMOs): CMOs provide downstream processing services to biopharmaceutical companies.
- Academic and Research Institutes: Downstream processing is used for research purposes in academic and research settings.
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Regional Growth Dynamics:
Based on region, the market across North America held the lion’s share in 2020, garnering around two-fifths of the global market. The Asia-Pacific region, on the other hand, is expected to cite the fastest CAGR of 14.6% by the end of 2030. The other provinces studied in the report include Europe and LAMEA.
Competitive Landscape:
- Repligen Corporation
- Thermo Fisher Scientific Inc.
- Merck & Co., Inc.
- Boehringer Ingelheim
- Lonza Group AG
- Eppendorf AG
- 3M Company
- Finesse Solutions, Inc.
- Sartorius Stedim Biotech S.A.
Recent developments:
- Continuous Bioprocessing: There has been an increased focus on continuous bioprocessing as an alternative to traditional batch processing. Continuous processing offers advantages such as increased productivity, reduced footprint, and improved product quality. This trend is driven by the need for more efficient and cost-effective production methods.
- Single-Use Technologies: The adoption of single-use bioprocessing systems has continued to grow. These systems reduce the risk of contamination, minimize the need for cleaning and sterilization, and enhance flexibility in biomanufacturing. Single-use technologies have gained popularity for their convenience and cost-effectiveness.
- Improved Chromatography Resins: Advancements in chromatography resins have led to higher binding capacities and improved selectivity, allowing for more efficient protein purification. Novel resins are being developed to streamline downstream processes.
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Key Questions Answered in the Intelligent Study
What is the market size and growth rate of the global and regional market by various segments?
What is the market size and growth rate of the market for selective countries?
Which region or sub-segment is expected to drive the market in the forecast period?
What Factors are estimated to drive and restrain the market growth?
What are the key technological and market trends shaping the market?
What are the key opportunities in the market?
What are the key companies operating in the market?
Which company accounted for the highest market share?
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