ViiV Healthcare to present 23 abstracts from innovative HIV treatment and prevention portfolio at EACS 2023

ViiV Healthcare to present 23 abstracts from innovative HIV treatment and prevention portfolio at EACS 2023

• Key data to be presented include long-term and real-world data from ViiV Healthcare’s portfolio of medicines, including long-acting and 2-drug regimens.

London, 18 OCTOBER 2023 – ViiV Healthcare, the global specialist HIV company majority owned by GSK, with Pfizer and Shionogi as shareholders, today announced the presentation of key abstracts highlighting the breadth of its approved and investigational medicines at the 19th Annual European AIDS Conference (EACS2023) being held in Warsaw, Poland from 18-21 October 2023. 

Kimberly Smith, M.D., MPH, Head of Research & Development at ViiV Healthcare, said: “Living well with HIV looks different for every individual, and we believe our upcoming presentations at EACS 2023 reflect our commitment and leadership to address the evolving needs of the HIV community.  Our latest data from our diverse portfolio and innovative pipeline explore real-world evidence that further evaluate the effectiveness, safety, and tolerability of 2-drug and long-acting regimens; new findings for broadly neutralizing antibodies; and long-term follow-up in heavily treatment-experienced individuals. We look forward to sharing these new insights with the scientific and HIV communities at EACS 2023.”

Key data to be presented at EACS 2023 by ViiV Healthcare will include:

Strengthening clinical and real-world evidence (RWE) across our treatment portfolio: New real-world findings for the long-acting regimen of Vocabria (cabotegravir injection) and Rekambys (rilpivirine long-acting injectable suspension) (CAB+RPV LA) in clinical settings across Europe will be presented at EACS. ViiV Healthcare will share 12-month European findings from the SOLAR study, the first head-to-head, phase IIIb study of the complete long-acting injectable regimen of CAB+RPV LA compared with daily oral Biktarvy (bictegravir/emtricitabine/tenofovir alafenamide [BIC/FTC/TAF]).[i]

Findings for the 2-drug regimen, Dovato (dolutegravir, lamivudine [DTG/3TC]), will include three-year effectiveness, safety, and tolerability outcomes among people living with HIV in a real-world German cohort and data from a large observational cohort across Europe.[ii]^,[iii] Additional data to be presented will include a review of real-world experience of DTG+3TC in people living with HIV over the age of 50, as well as in treatment-naïve people with a low CD4+ cell count or high viral load at baseline.[iv]

Long-term data in heavily treatment-experienced (HTE) populations: Long-term, five-year data from the phase III BRIGHTE clinical trial, which studied the use of Rukobia (fostemsavir) in heavily-treatment experienced populations with multi-drug resistant HIV-1, will be presented. New data will report on long-term safety and the impact of immune recovery in adults receiving fostemsavir, along with fostemsavir’s impact on immune and inflammation-related biomarkers in these patients.[v]^,[vi]

Advancing new mechanisms of action in HIV research: New phase IIa, proof of concept study findings will be presented from the BANNER study of N6LS (VH3810109), a novel, investigational, broadly neutralizing antibody (bNAb). Safety and tolerability findings following a single IV infusion or subcutaneous injection will be shared. .[vii] N6LS is a component of the company’s ultra-long-acting medicine development strategy, specifically being investigated for dosing intervals of at least every four months.

Here is a list of ViiV Healthcare-sponsored or supported studies being presented at EACS 2023:

[i] De Los Santos Gil I, et al. SOLAR 12-month European results: randomized switch trial of CAB+RPV LA vs. oral BIC/FTC/TAF. Presented at European AIDS Society Conference (EACS). October 2023.

[ii] Noe S, et al. 3-year outcomes for dolutegravir (DTG) + lamivudine (3TC) in ART-naive and pre-treated people living with HIV-1 (PLHIV) in Germany: real-world data from the German URBAN cohort. Presented at European AIDS Society Conference (EACS). October 2023.

[iii] Mussini C, et al. Dolutegravir + lamivudine 2-drug regimen is highly effective and well-tolerated in a real-world clinical setting in Europe: data from the COMBINE-2 Study. Presented at European AIDS Society Conference (EACS). October 2023.

[iv] Letang E, et al. Systematic literature review of real-world experience with the

2-drug regimen dolutegravir + lamivudine (DTG + 3TC) in people with HIV-1 (PWH) aged ≥50 years. Presented at European AIDS Society Conference (EACS). October 2023.

[v] Libre J, et al. Long-term safety and impact of immune recovery in heavily treatment-experienced adults receiving fostemsavir for up to 5 years in the BRIGHTE study. Presented at European AIDS Society Conference (EACS). October 2023.

[vi] Castagna A, et al. Sustained improvements in biomarkers observed with fostemsavir in heavily treatment-experienced adults with multidrug-resistant HIV-1 from the phase 3 BRIGHTE study through Week 240. Presented at European AIDS Society Conference (EACS). October 2023.

[vii] Leone P, et al. VH3810109 (N6LS) Was Safe and Well Tolerated Among Antiretroviral Therapy-Naïve Adults Living with HIV-1: Results from the Phase IIa BANNER Study. Presented at European AIDS Society Conference (EACS). October 2023.