AlzeCure presents new preclinical data with NeuroRestore ACD856 at leading Alzheimer's conference
AlzeCure Pharma AB (publ) (FN STO: ALZCUR), a pharmaceutical company that develops small molecule drug candidates for CNS diseases, focusing on Alzheimer's disease and pain, today announced that the company's presentation at the Alzheimer's conference AD/PD 2024, regarding new preclinical data with its leading clinical drug candidate NeuroRestore ACD856, which is being developed with a focus on Alzheimer's disease, is now available on the company's website.
The abstract, titled ACD856 is a biased positive allosteric modulator of Trk-receptors – Enhances neurite outgrowth but do not affect pain signaling, was presented by Pontus Forsell, Head of Discovery and Research at AlzeCure, and includes new preclinical data with the lead clinical drug candidate ACD856, which is part of the NeuroRestore platform.
Data from the study show that ACD856 functions as a so-called biased PAM (positive allosteric modulator), i.e. that the substance potentiates certain signaling pathways but not others, which means that the substance can have potent effects and at the same time maintain a good safety profile. The results show that ACD856 can stimulate nerve cell growth, something that is important for communication between nerve cells. In addition, the substance improves memory and learning ability in preclinical models. In contrast, pain signaling is not affected, which indicates a selective stimulation of specific signaling pathways. ACD856 is a Trk-PAM and enhances BDNF and NGF signaling, which among other things play an important role in normal nerve cell function and maintaining brain health.
The substance is under clinical development as a symptom-relieving treatment for disease states where the cognitive ability is impaired, for example in Alzheimer's disease. New preclinical data also suggest that ACD856 has potential protective and disease-modifying effects.
”These new data with ACD856 show that the substance has growth-stimulating and memory-enhancing effects, without affecting pain signaling. This selective stimulatory effect bodes well for further clinical development,” said Pontus Forsell.
”With the positive clinical results we previously obtained with ACD856, as well as additional new preclinical results supporting a disease-modifying effect, we have a promising drug candidate in the Alzheimer's field, which is gratifying considering the very large medical need," said AlzeCure Pharma’s CEO Martin Jönsson.
The authors of the abstract are Pontus Forsell, Veronica Lidell, Azita Rasti, Gunnar Nordvall and Johan Sandin.
The presentation is available on AlzeCure’s website: (https://www.alzecurepharma.se/en/presentations-and-interviews/).
