Cancer Cachexia Market to Grow at a CAGR of 4.8% Over the Next Decade

The global cancer cachexia market is projected to grow significantly, reaching an estimated value of USD 4,034 million by 2032, up from USD 2,554 million in 2022, reflecting a compound annual growth rate (CAGR) of 4.8% during the forecast period from 2022 to 2032. This growth is driven by several factors, including the rising prevalence of cancer, which consequently increases the incidence of cancer cachexia, a multifactorial syndrome characterized by weight loss, muscle atrophy, fatigue, and significant metabolic alterations.

Key growth factors for the market include increased funding for research and development, which has led to the emergence of new therapeutic options and clinical trials aimed at addressing the complex mechanisms underlying cachexia. Recent developments in combination therapies and targeted treatments are showing promise in managing the condition more effectively. For instance, the launch of ARTHEx biotech’s ENTRY platform and substantial grants, such as the USD 25 million awarded to the Rutgers Cancer Institute of New Jersey for cancer cachexia research, highlight ongoing efforts to innovate and improve patient outcomes.

However, the market also faces significant challenges. High treatment costs and limited reimbursement options, especially in developing countries, pose barriers to widespread adoption. Additionally, the complexity and underdiagnosis of cancer cachexia complicate treatment efforts, as healthcare providers often focus primarily on the underlying cancer, neglecting the cachexia component.

Recent advancements include the exploration of progestogens, corticosteroids, and novel combination therapies to alleviate cachexia symptoms. Hospital stores, retail pharmacies, and online pharmacies are playing crucial roles in distributing specialized nutritional and medical products, ensuring that patients have continuous and convenient access to necessary treatments.

Overall, while the cancer cachexia market is poised for growth, addressing the challenges of high costs, underdiagnosis, and the complexity of the disease will be crucial for maximizing therapeutic success and improving patient quality of life​.

Key Takeaways

• Market Growth: The cancer cachexia market is projected to grow at a 4.8% CAGR, reaching USD 4,034 million by 2032, from USD 2,554 million in 2022.
• Progesterone Dominance: Progesterone therapy, leading with a 5.4% CAGR, was considered the safest option for cancer cachexia treatment in 2022.
• Hospital Pharmacy: Hospital pharmacies held the largest market share in 2022, attributed to increased hospitalization cases.
• Weight Loss Stabilizers: The weight loss stabilizers segment, with a 4.2% CAGR, is vital for countering weight loss and improving patients’ quality of life.
• Cancer Frequency: Rising global cancer cases boost the market; WHO reported 18.1 million new cases in 2018.
• Opportunity: The growing relevance of cancer and cachexia drives R&D, leading to a strong product pipeline for therapeutic drugs.
• Combination Therapy: Combination therapies are increasingly popular among healthcare professionals for better outcomes.
• Regional Dominance: North America holds over 45.1% market share, while APAC is set to grow at a higher CAGR.

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Cancer Cachexia Market Key Segments

Based on Therapeutics

• Progestogens
• Corticosteroids
• Combination Therapies
• Others

Based on Distribution Channel

• Hospital
• Retail Pharmacy
• Online Pharmacy

Based on the Mode of action

• Appetite Stimulators
• Weight Loss Stabilizers
• Others

Key Regions

• North America (The US, Canada, Mexico)
• Western Europe (Germany, France, The UK, Spain, Italy, Portugal, Ireland, Austria, Switzerland, Benelux, Nordic, Rest of Western Europe)
• Eastern Europe (Russia, Poland, The Czech Republic, Greece, Rest of Eastern Europe)
• APAC (China, Japan, South Korea, India, Australia & New Zealand, Indonesia, Malaysia, Philippines, Singapore, Thailand, Vietnam, Rest of APAC)
• Latin America (Brazil, Colombia, Chile, Argentina, Costa Rica, Rest of Latin America)
• Middle East & Africa (Algeria, Egypt, Israel, Kuwait, Nigeria, Saudi Arabia, South Africa, Turkey, United Arab Emirates, Rest of MEA)

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Key Players Analysis

Eli Lilly and Company is actively engaged in developing treatments for cancer cachexia, focusing on innovative drug solutions to address the syndrome’s complex pathology. The company’s research is centered on understanding the multifactorial nature of cachexia, which includes inflammation and muscle wasting. Lilly’s approach includes exploring targeted therapies that can modulate these underlying mechanisms, aiming to improve patient outcomes. Their pipeline includes novel candidates in various stages of clinical trials, reflecting their commitment to advancing therapeutic options for this debilitating condition​.

Pfizer Inc. is making significant strides in the cancer cachexia sector with ongoing clinical trials for potential treatments. One of their key investigational drugs, PF-06946860, is currently in Phase 1 trials, targeting cachectic non-small cell lung cancer patients. Pfizer’s research focuses on understanding the effectiveness of their drug candidates in alleviating symptoms associated with cachexia, such as weight loss and muscle wasting. The outcomes of these trials are anticipated to enhance treatment protocols and expand therapeutic options available to healthcare providers​.

Bristol-Myers Squibb Company is leveraging its extensive oncology portfolio to address cancer cachexia. The company is involved in the development of combination therapies that integrate multiple pharmacological agents to target the syndrome’s complex mechanisms. These efforts are aimed at improving the management of cachexia symptoms and enhancing patient quality of life. Bristol-Myers Squibb’s innovative approach underscores its commitment to transforming cancer care and addressing the unmet needs of patients suffering from cachexia.

Sanofi’s work in the cancer cachexia market involves the development of supportive care therapies designed to mitigate the adverse effects of cachexia on cancer patients. Their research is directed towards enhancing the efficacy of existing treatments and exploring new therapeutic avenues to stabilize weight loss and improve appetite. Sanofi’s strategic focus includes both pharmacological and non-pharmacological interventions, aiming to offer comprehensive care solutions for patients experiencing this syndrome​.

Teva Pharmaceutical Industries Ltd. is contributing to the cancer cachexia market through the development of drugs that address the syndrome’s various pathological aspects. Their portfolio includes medications that act as appetite stimulators and weight loss stabilizers, aiming to provide relief from the severe symptoms of cachexia. Teva’s approach combines advanced research with clinical insights to create effective treatment protocols that can be integrated into broader cancer care strategies​.

Cancer Cachexia Market Key Players:

• Eli Lilly and Company
• Pfizer Inc.
• Bristol-Myers Squibb Company
• Sanofi
• Teva Pharmaceutical Industries Ltd.
• ANI Pharmaceuticals
• Hikma Pharmaceuticals PLC
• SkyePharma
• Other Key Players

Cancer Cachexia Market Report Scope >> Market Value (2022): USD 2,554 Million || Forecast Revenue (2032): USD 4024 Million || CAGR (2023-2032): 4.8% || Base Year Estimation: 2023 || Historic Period: 2019-2022 || Forecast Period: 2024-2033.

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