STORM Therapeutics to Present Interim Phase 1 Clinical Data on its METTL3 RNA Methyltransferase Inhibitor STC-15 at ASCO 2024

STC-15 is the first METTL3 inhibitor to enter clinical development

Clinical data will include safety, pharmacology, target modulation, and clinical activity

24 May 2024, Cambridge, UK: STORM Therapeutics Ltd. (STORM), the clinical stage company pioneering cellular reprogramming through RNA modifications to treat disease, today announces that it will be presenting interim clinical data on its first-in-class lead product, STC-15 at the upcoming American Society of Clinical Oncology (ASCO) Annual Meeting, taking place in Chicago, US from May 31 to June 4, 2024.

The poster presentation, entitled ‘Phase 1 Dose Escalation and Cohort Expansion Study Evaluating Safety, PK, PD and Clinical Activity of STC-15, a METTL3 Inhibitor, in Patients with Advanced Malignancies’, describes findings from STORM’s ongoing dose escalation and expansion Phase 1 clinical study to evaluate STC-15, an oral and highly selective small molecule inhibitor of METTL3, in advanced cancer patients. These interim results will focus on safety, pharmacokinetics, target modulation and tumor assessments to support future clinical studies. STC-15 is the first molecule specifically targeting an RNA methyltransferase enzyme to enter clinical development.

Preclinical data has demonstrated that METTL3 inhibition stimulates immune cells and activates interferon pathways, leading to the destruction of tumor cells. The poster presentation will detail the study design, patient demographics, safety data, pharmacokinetics, METTL3 target engagement, mechanistic biomarker data, and assessments of clinical activity.  

Details of the poster presentation are as follow:

Poster Title: Phase 1 dose escalation and cohort expansion study evaluating safety, PK, PD and clinical activity of STC-15, a METTL3 inhibitor, in patients with advanced malignancies

Presenter: Justin Moser at HonorHealth Research Institute

Authors: Justin Moser¹, Kyriakos Papadopoulos², Jordi Rodon Ahnert³, Yaara Ofir-Rosenfeld⁴, Josefin-Beate Holz⁴

Organizations: ¹HonorHealth Research Institute, ²START San Antonio, ³The University of Texas MD Anderson Cancer Center, ⁴Storm Therapeutics Ltd

Poster Session: Developmental Therapeutics—Immunotherapy

Session Date and Time: Saturday June 1, 2024, 9:00 AM - 12:00 PM CDT

Poster Board Number: 65

Abstract Presentation Number: 2586

The Abstract is available on the ASCO online itinerary planner here, and on the STORM website here.