PUBLICATION DEMONSTRATES POTENTIAL FOR MULTI-MARKER CTC PROFILING IN EARLY PROSTATE CANCER

Parsortix enriched CTCs detected at high rates in localised disease

Multi-marker profiling of CTCs could support development of targeted therapies and help stratify patients in clinical trials

ANGLE plc (AIM:AGL OTCQX:ANPCY), a world-leading liquid biopsy company with innovative circulating tumour cell (CTC) solutions for use in research, drug development and clinical oncology, is pleased to announce the publication of research investigating a panel of known prostate cancer gene transcripts in CTCs, undertaken by the Comprehensive Cancer Center at the Medical University of Vienna.

Researchers used the Parsortix^® system to isolate and harvest CTCs from 38 localised and metastatic prostate cancer patients. CTCs were then analysed using a range of molecular techniques which enabled multiple biomarkers to be simultaneously analysed.

The study demonstrated the highly effective capture of CTCs using the Parsortix system, with 67% of localised prostate cancer patients positive for CTC biomarker(s) at baseline and 77% positive for CTC biomarker(s) after treatment.

The findings indicated a strong correlation between specific CTC biomarkers and clinical parameters, such as tumour grade and stage, suggesting that multi-marker CTC analysis could aid in risk stratification for patients. This adds to the body of evidence supporting ANGLE’s large pharma strategy, highlighting the potential to inform patient selection for clinical trials in the development of targeted therapies.

Chief Scientific Officer, Karen Miller, commented:

“This study supports our pharma services business by demonstrating how a Parsortix-enriched, CTC-based multi-marker approach can enhance the development of targeted therapies and improve patient stratification in clinical trials. This approach could ultimately lead to the development of new classes of drugs which are more targeted and provide better outcomes for patients, all of which may require a Parsortix-based companion diagnostic to support regulatory clearance.”

The research, published as a peer-reviewed publication in the journal Clinical and Experimental Metastasis, is available online at https://angleplc.com/resources/publications/.