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14-Feb-2025

Application areas and exposure principles for in vitro lung cell research

(PresseBox) (Waldkirch, 14.02.2025) 

Explore Application Areas and Exposure Principles for in vitro Inhalation Research

VITROCELL® devices are designed to evaluate the potential health risks of inhalable substances without relying on laboratory animals. These systems expose lung cells at the air-liquid interface, simulating real-world inhalation conditions.

A newly released video presentation highlights key in vitro exposure systems designed for all types of aerosols, including:
  • Gases, complex mixtures, and particles in continuous flow
  • Liquids and suspensions via single droplet sedimentation
  • Dry powders in minimal quantities
Watch the video on our YouTube channel Exposure Systems for in vitro inhalation research

Comprehensive Cell Exposure Systems
VITROCELL® offers a variety of advanced cell exposure systems capable of directly exposing respiratory tract cells to gases, particles, and complex mixtures.

Key steps of the exposure process:
  1. Cell Cultivation: Cells are cultured on permeable membrane inserts.
  2. Exposure Setup: The inserts are placed in exposure systems maintained at 37°C. The basal side of the cells receives nutrients through the membrane, while the apical side remains exposed to airborne substances at the air-liquid interface, closely mimicking human respiratory conditions.
  3. Exposure Process: Airborne compounds interact directly with the cells without interference from a liquid barrier.
  4. Post-Exposure Analysis: The membrane inserts are removed, and the cells undergo standard endpoint analyses.
Supporting the Reduction of Animal Testing
VITROCELL® systems are widely used in leading laboratories worldwide, helping reduce the need for animal testing in inhalation research. Their customers include:
  • Research institutes
  • Industrial and pharmaceutical laboratories
  • Contract research organizations
  • Regulatory authorities
VITROCELL® is a trusted partner in driving innovative advancements in toxicological and inhalation research globally.

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Last Updated: 14-Feb-2025