Knee Hyaluronic Acid Injections Market to Reach USD 3,973.2 Million by 2035 at a 5.7% of CAGR, Amid Rising Osteoarthritis Cases

Knee Hyaluronic Acid Injections Market

The global knee hyaluronic acid injections market is poised for steady growth, with its valuation expected to rise from USD 2,282.4 million in 2025 to USD 3,973.2 million by 2035, registering a CAGR of 5.7% over the forecast period. The market recorded a revenue of USD 2,167.2 million in 2024, highlighting its strong demand as a non-surgical treatment option for knee osteoarthritis.

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One of the primary growth drivers of the market is the increasing prevalence of knee osteoarthritis, driven by factors such as obesity, sedentary lifestyles, repetitive joint injuries, and the natural aging process. As this degenerative disease leads to chronic pain, stiffness, and inflammation, patients are actively seeking treatment options to maintain mobility and delay surgical interventions.

Hyaluronic acid injections serve as a widely adopted non-operative intervention, offering viscosupplementation that improves joint lubrication, reduces pain, and enhances mobility. This treatment has gained traction as it provides significant symptomatic relief and delays the need for invasive procedures like knee replacement surgeries, making it a preferred choice among healthcare providers and patients.

Key Takeaways:

• The knee hyaluronic acid injections market is projected to grow at a 5.7% CAGR, reaching USD 3,973.2 million by 2035.
• Increasing cases of knee osteoarthritis due to aging, obesity, and joint injuries are driving market demand.
• Hyaluronic acid injections provide a non-surgical treatment option, improving joint lubrication and mobility.
• Rising preference for minimally invasive pain management solutions is fueling market expansion.

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Key Drivers of Growth

Increasing Prevalence of Osteoarthritis:

The rising incidence of osteoarthritis, exacerbated by factors like obesity, sedentary lifestyles, and joint injuries, drives demand for non-surgical treatments like hyaluronic acid injections.

Aging Population and Lifestyle Factors:

The natural aging process and lifestyle factors contribute to joint degeneration, leading to increased demand for treatments that alleviate symptoms without requiring surgery.

Non-Operative Interventions:

Hyaluronic acid injections are a preferred non-operative intervention, providing symptomatic relief by lubricating the knee joint and enhancing mobility.

Patient Preference for Minimally Invasive Treatments:

Patients increasingly seek treatments that delay or avoid surgical interventions, further driving demand for hyaluronic acid injections.

Regional Insights

North America and Europe: Currently dominate the market due to high prevalence of osteoarthritis and well-established healthcare systems.

Asia-Pacific: Expected to grow rapidly due to increasing healthcare investments and rising awareness about non-surgical treatments.

Challenges

Regulatory Compliance: Ensuring compliance with evolving healthcare regulations can be challenging for manufacturers.

Cost and Accessibility: High costs associated with hyaluronic acid injections may limit adoption in some regions.

The market’s growth reflects its critical role in addressing osteoarthritis through non-surgical interventions, driven by increasing demand for effective and minimally invasive treatments.

Knee Hyaluronic Acid Injections Industry Analysis, By Key Market Players

• Sanofi S.A.
• Bioventus LLC
• Ferring B.V.
• Zimmer Biomet
• Seikagaku Corporation
• Fidia Farmaceutici s.p.a.
• Anika Therapeutics, Inc.
• LG Chem
• OrthogenRx
• Hanmi Pharm.Co.,Ltd.
• Chugai Pharmaceutical Co., Ltd.
• Haohai Biological Technology
• Meiji Seika Pharma co. ltd
• Hangzhou Singclean Medical Products Co.,Ltd
• Others

Knee Hyaluronic Acid Injections Industry Outlook, By Key Segments

By Product:

• Single injection knee hyaluronic acid injections
• Three injection knee hyaluronic acid injections
• Five injection knee hyaluronic acid injections
• Next generation (steroid combination)

By End User:

• Hospitals
• Ambulatory surgical centers
• Orthopedic clinics
• Retail pharmacies
• Online sales

By Region:

• North America
• Latin America
• Western Europe
• Eastern Europe
• South Asia and Pacific
• East Asia
• Middle East and Africa (MEA)

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